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Mechanistic studies of neurodegenerative diseases, such as VaD and AD, have shown that pathological processes, including neuronal damage and synaptic loss, are strongly associated with ferroptosis (Adeniyi et al., 2023

CAT: catalase DHODH: Dihydroorotate dehydrogenase FSP1: Ferroptosis suppressor protein 1 TEM: Transmission electron microscopy AMPK: Adenosine monophosphate-activated protein kinase M-TOR: Mammalian target of rapamycin PCa: Prostate cancer References Kim EH, Larson JA, Andriole GL

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Variants in the CETP gene affect levels of HDL cholesterol by reducing the amount, and not the specific lipid transfer activity, of secreted CETP