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By delivering light directly into the joint via platforms such as OFA, this approach overcomes the tissue penetration limits of transcutaneous PBM, enabling precise modulation of the articular microenvironment

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6 Conclusions and perspectives This review highlighted the pivotal role of inflammation in EDC and discussed inflammation-targeted therapeutic strategies, including anti-inflammatory agents, antioxidants, gut microbiota modulation, herbal and natural products, acupuncture, and stem cell therapy