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10.3389/fneur.2019.01245 208 JaggarM.ReaK.SpichakS.DinanT

For example, Brenton et al

Cytokines secreted by IL-2-activated lymphocytes induce endogenous nitric oxide synthesis and apoptosis in macrophages

The physiological relevance of UA and its conjugates was confirmed through metabolic profiling of malignant mammary tissues 31

All cell lines were cultured according to the manufacturers instructions

Thus, it needs to be cleared out quickly to prevent cell and DNA damage, which can lead to cancerous mutations.[ref] Two well-studied genetic variants have different ways of reaching the same endpoint: ~ an alcohol dehydrogenase (ADH1B) variant that speeds up the conversion to acetaldehyde, thus creating a buildup of acetaldehyde ~ an acetaldehyde dehydrogenase (ALDH2) variant that slows down the conversion from acetaldehyde to acetic acid, again creating a buildup of acetaldehyde