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Description

Thornton et al., 2003)

Caenepeel, C

(2022) 64:S28191

doi: 10.1093/brain/aww251

Structural analysis showed that when human DNMT1 was not bound to DNA, the RFTS domain could bind to the MTase domain directly through a hydrogen bond and bind indirectly through a CXXCBAH1 linker, thus forming an auto-inhibitory conformation