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However, there is an increasing need for animal models of depression other than the currently available models of behavioural despair (forced swim test and tail suspension test)

However, the success of this treatment in solid tumors has been challenged by the tumor-antigen heterogeneity, impaired CAR-T cell trafficking and infiltration, and the presence of an immunosuppressive tumor microenvironment (TME) [6]

One of the key regulators of this response is the transcription factor hypoxia-inducible factor (HIF) (55)

However, Ssu72 is restored within a knockout genetic background rather than introduced as an independent intervention

A large number of studies also demonstrate its positive impact on overall health and well-being