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Hydroxysafflor yellow A (HYA) reduces allergic symptoms in AR mice by decreasing the levels of RORt, STAT3, and p-STAT3 while activating the Nrf2/HO-1 pathway [174]

While experimental and computational studies suggest that both the sulfur and selenium variants proceed through a double [2,3]-sigmatropic rearrangement, the sulfenylation reagents behave as coupling partners while organoselenium reagents can be employed catalytically