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(4) Dose titration: Therapy is typically initiated at low doses and titrated gradually to achieve optimal symptom control while minimizing adverse effects, with the goal of identifying the lowest effective daily dose

This theory faces contradictions, such as HPA axis hypofunction being limited to certain patients, no early-stage changes in ME/CFS, and heightened immunosuppressive effects of glucocorticoids in these patients

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The Zn-2p XPS spectra (Fig

(157) have reviewed forty one articles including major RCTs that have studied the effect on NAC on respiratory conditions including chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, bronchiectasis, chronic bronchitis and cystic fibrosis with respect to the side effects of NAC at doses between 600 mg per day to 3,000 mg per day

Therefore, its deficiency can lead to clinical manifestations in the blood and nervous systems, affecting cell replication and fatty acid metabolism [49]