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SBS2 and SBS13 mutational signatures, which are associated with the AID/APOBEC activity of cytidine deaminases and innate immune response, are frequently detected in LCNS cohorts and as well as in a variety of other cancer cohorts including within smoking lung cancer [39, 52, 53]

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Future hypertension interventions should focus on smokers, individuals exposed to SHS, drinkers, and, in particular, concurrent smokers and drinkers.