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The central changes observed during paclitaxel-induced CIPN are likely to be caused by the neurotoxic effects triggered by this antitumor drug at the periphery because paclitaxel has a very low ability to cross the bloodbrain barrier [148]

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Supplementary material The Supplementary Material for this article can be found online at: Abbreviations ACTH, Adrenocorticotropic hormone

ALT, glutamic-pyruvic transaminase

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