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In glioblastoma (GBM) patients, oxidative stress leaded to elevated APE1 levels, which increased repair of the AP sites from the chemotherapy, leading to increased drug resistance

Conclusions Interrupting iron utilization is a validated mechanism for eliminating malaria parasites, but ARTs exhibit unique and superior efficacy owing to their ability to interact with heme, disrupt hemozoin formation, and perturb iron homeostasiseffects that extend beyond the simple iron sequestration achieved by chelators

Some symptom worsening may reflect medication side effects, coinfections, autonomic dysfunction, or unrelated illness

4B) via increasing the affinity for its substrate glucose-6-phosphate (G6P) (Fig

Ann Allergy Asthma Immunol 95:217-226

doi: 10.3389/fcell.2023.1277686