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Glycolysis is regulated by key enzymes, such as hexokinase and phosphofructokinase-1 ( Figure 2 )

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Since there is substantial evidence that oxidative damage is involved in the processes of CIPN, it is not surprising that enormous efforts have been made to mitigate the impact of chemotherapy regimens on the quality of life of patients by using antioxidants as potential protective interventions during chemotherapy-based treatment