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Therapeutic stress affects the fidelity of DNA replication (from high fidelity to low fidelity DNA replication) by down-regulating precise DNA polymerases (POL, POL), mismatch repair genes and homologous recombination pathways, as well as up-regulating specialized error-prone DNA polymerases, coordinately inducing DNA mutagenesis and microsatellite instability [49, 80, 81]

Then, you have the reconstituted solution

This is determined by the intrinsic architecture of the database

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