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As mentioned above, SIHUMIx established a stable consortium during the first six to eight days of in vitro cultivation in the bioreactor system

Procyanidin oligomers and polymers reach the large intestine where they are subjected to microbial metabolism yielding e.g., phenylvalerolactones (see section 6.1 Pre-systemic metabolism: role of gut microbiota)

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doi: 10.1016/j.brainresbull.2008.12.001 Summary Keywords bilirubin, dopaminergic neurons, inflammation, neurodevelopment, oxidative stress, Parkinson's disease Citation Zhang Y, Liu H, Cao H, Deng M, Han Z, Wu X, Wan Q, Wang R, Xu Y, Lai J, Jiang Y, Gong L, Liu Z, Lai K and Shi H (2026) Neuroprotective role of bilirubin in Parkinson's disease