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Analysis in larger and more racially and ethnically diverse population will be needed to confirm and understand the generalizability of these findings Disclosures: Cristian Sanchez Torres: Nothing to Disclose, Ana Ramirez: Nothing to Disclose, Scott Gillespie: Nothing to Disclose, Helaina Huneault: Nothing to Disclose, Jack Knight-Scott: Nothing to Disclose, Adina Alazraki: Nothing to Disclose, Geetika Khanna: Nothing to Disclose, Claudia Yaranga: Nothing to Disclose, Nicola Santoro: Nothing to Disclose, Liliana Aguayo: Nothing to Disclose, Shasha Bai: Nothing to Disclose, Jean Welsh: Nothing to Disclose, Miriam Vos: Nothing to Disclose 865 EFFICACY OF NON INVASIVE TESTS (NITS) IN DIFFERENTIATING METABOLIC DYSFUNCTION-ASSOCIATED FATTY LIVER DISEASE (MAFLD) AND METABOLIC-ALCOHOL ASSOCIATED LIVER DISEASE (METALD)-META-ALD STUDY Harsh Tevethia 1 Guresh Kumar 2 Shiv Kumar Sarin 2 , 1 Institute of liver and biliary sciences,New Delhi India, 2 ILBS Background: MAFLD represents a global pandemic for liver diseases with a prevalence of 22% to 51% worldwide

However, the poor fidelity to the in vivo conditions limits its efficacy, widening the translational gap between preclinical studies and clinical trials ( Hydrogel-based cell culture systems, spheroids and organoids, or their combination currently represent valid 3D cell culture models ( e.g

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Nat Immunol (2017) 18(3):28392