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Biomimetic cell membrane coating combined with stroma-degrading enzymes (e.g., hyaluronidase) has increased accumulation to 15%22% ID/g in patient-derived xenografts, offering a promising solution ( Regarding clinical translation, several MSN-related nanoplatforms have entered human trials

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For example, oxPLs bind efferocytosis receptors and effectively compete for apoptotic cell recognition

187 HNP1 under homeostatic physiological circumstances have not been reported to be involved in any immunomodulatory activity, however in an inflammatory state HNP1 recruits leukocytes in a positive feedback-loop, 188 stimulates the production of IL-6 and IL-8 via the p38 and ERK1/2 MAPK-dependent signaling pathways

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found abundant expression of xCT on the surface of KSHV + PEL cells, which not only increases intracellular GSH levels to reduce oxidative damage caused by ROS but also activates the AKT pathway-dependent proliferation of B cells, ultimately promoting the progression of PEL