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2.5 Disrupted proteostasis and autophagy-lysosomal dysfunction The autophagy-lysosomal pathway (ALP) and ubiquitin-proteasome system (UPS) are critical for degrading misfolded proteins

Kelso TB, Shear CR, Max SR

A large body of research (1) confirms that folate deficiency something that is incredibly common is frequently seen in those with depression, and is remediated with the supplementation of this nutrient

Metabolism of exogenous S-adenosylmethionine in isolated rat hepatocyte suspensions: methylation of plasma-membrane phospholipids without intracellular uptake

The selectivity profile against related SAM-dependent methyltransferases has been characterized in the same publication series