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In vivo , in the hippocampal tissues of mice exposed to PS-MPs, there was a significant increase in the mRNA expression levels of inflammation-related genes ( Tnf-a , Il-1b , Il-6 , Cxcl10 , and Mcp-1 ), indicating heightened inflammatory responses ( In vitro studies indicate PS has the capacity to bind to and activate BV2 microglial cells, thereby inducing pro-inflammatory reactions and activating inflammatory pathways, such as the NF-B pathway, which results in the production of pro-inflammatory cytokines ( in vitro and in vivo evidence converge to highlight oxidative stress and subsequent neuroinflammation as pivotal events in MPs-induced neurotoxicity

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10.1038/s41586-024-07871-6 27 GuoY.HanZ.ZhangJ.LuY.LiC.LiuG

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