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The persistence of commensals in various niches of the gut likely contributes to a hosts ability to resist pathogen colonization through competitive exclusion [55], and the enhanced citrate metabolism could be a good indication of microbe-microbe mutualism

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Although constitutive expression of COX-2 in hepatocytes and enhanced production of COX-2-derived PGE2 in white adipose tissue protect against diet-induced insulin resistance and maintain intermittent fasting-elicited insulin sensitivity benefits by promoting systemic energy expenditure and reducing inflammatory response, 107,112 epidydimal adipose tissue COX-2 is potently and positively related to impaired glucose and insulin tolerance in obese rats