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The disease pathogenesis is based on the presence of autoantibodies directed against proteins on the surface of keratinocytes, called desmogleins

shows that knockdown of Arachidonate 15-Lipoxygenase (ALOX15) decreases erastin-induced and RSL3-induced cellular ferroptosis, on the contrary exogenous overexpression of ALOX15 enhances the effects of these compounds

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It is an antioxidant that prevents damage from reactive oxygen species to cellular components that are important

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