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Specifically, the intervention group showed a marked decrease in serum malondialdehyde levels, reduction in the neutrophil-to-lymphocyte ratio, and increase in catalase levels

It seems that HQ binding is rather flexible in the active site, agreeing with the in silico simulations shown above, and does not have one specific orientation in contrast to L-tyrosine and L-dopa (Fig

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Covalent disulfide bridges can affect the shape of a protein