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377 Iron overload, following increased intake, which may in particular result from the use of iron-containing implants widely employed in orthopaedic surgery, 378 or can occur after haemorrhagic stroke, results in compensatory upregulation of glial iron transporters, and down-regulation of neuronal iron transporters, both aimed at neuroprotection

The top two drugs cladribine and gemcitabine were predicted to be effective in every cancer model and thus to be universal drug candidates, while having only minimal effect on the ATP maintenance of any control model (Fig

However, further investigations are needed to validate the above hypothesis

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