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After dewaxing, the sections were stained with hematoxylin (H9627, Sigma-Aldrich) for 3 min at room temperature, and then were treated with eosin (E4009, Sigma-Aldrich) for 20 s

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While specific downregulation kinetics for Dihexa haven't been thoroughly characterized in published literature, research on HGF and c-Met signaling in other contexts suggests receptor density begins declining within 2448 hours of sustained agonist exposure, with maximum downregulation occurring around 72 hours

doi: 10.1056/NEJMra2026131 77 FakhrolmobasheriM.Mazaheri-TehraniS.KieliszekM.ZeinalianM.AbbasiM.KarimiF.et al

This is fibroblast activation translating into early collagen deposition

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