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Critically, conditionally essential nutrients, when supplied exogenously, correct a clinically relevant outcome measure (99,100) In the context of clinical nutrition, Grimble in 1993 proposed five criteria to define conditionally essential nutrients in humans, whereby their deficiency results in either: failure to maintain growth or nitrogen balance, organ dysfunction, delayed recovery, metabolic or clinical abnormalities (99)

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5 cGAS-STING signaling: a target for RA treatment According to the above description, cGAS-STING signaling primarily plays a pathogenic role in RA

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(2012) 7:e47647