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Not only does glutathione protect the immune system by reducing levels of oxidative stress and inflammation, but it also helps to fortify the immune system in two key ways 8, 9 : Plays a critical role in supporting T lymphocyte (white blood cell) function Activated T cells produce free radicals, which trigger the glutathione (GSH) response required to buffer the increasing levels of ROS and prevent cellular damage Stimulates production and activity of natural killer (NK) cells NK cells play a critical role in the innate immune defense system and are reliant upon adequate levels of GSH

Exhaled nitric oxide in high-altitude pulmonary edema: role in the regulation of pulmonary vascular tone and evidence for a role against inflammation

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Liu L, Zhang K, Sandoval H, Yamamoto S, Jaiswal M, Sanz E, Li Z, Hui J, Graham BH, Quintana A, Bellen HJ (2015) Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration

Mechanistic studies on three 2-oxoglutarate-dependent oxygenases of flavonoid biosynthesis