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Vitamin E inhibits CD95 ligand expression and protects T cells from activation-induced cell death

Cultured RAW 264.7 treated with 16.7 g/mL FONE with catalase (0, 5 and 15 U/mL), or FONE70 (0, 16.7 and 20 g/mL), or 20 g/mL FONE70 with 3-AT (0, 5, and 15 U/mL) for 24 h were collected

Besides importing from the extracellular environment, cells can synthesize serine from intracellular glucose through the de novo serine synthesis pathway (SSP), which is considered necessary for cancer cells (Locasale, 2013)

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Moreover, we have further validated our findings by using exogenous GSH as a positive control