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Note that participants in the previously published pilot study (14) are included in this manuscript due to the fact that the present analysis includes additional metabolites and comparison of all outcomes across product formulations

However, by the 1950s, the brand underwent a dramatic shift, leaning more into the image of the now iconic Marlboro Man

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If you cut too far, the wrapper leaf may come undone and leave you with a large mess of tobacco

Invariably these were intense and often painful discussions about something each clearly considered a hugely important and central part of who they now are