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Toxicol Appl Pharmacol 93:6271 National Toxicology Program

Kok, 2023, published by StatPearls, a blood alcohol concentration (BAC) of 0.40% or higher is considered potentially lethal, posing significant risks such as respiratory failure, coma, and death

IP3 may help liberate calcium ions (Ca) from internal cellular stores

34 Fenton reaction and lipid peroxidation in hepatotoxicity According to a more recent review by Dixon and Stockwell, 35 there are three essential hallmarks that define ferroptosis: the loss of lipid peroxide repair capacity by the phospholipid hydroperoxidase GPx4, the availability of redox-active iron, and the oxidation of PUFA-containing phospholipids . Although the term ferroptosis is new, the process of iron-dependent lipid peroxidation (LPO) as a mechanism of cell death in the liver has been recognized for 60 years

Vicente, A

10.1016/j.neulet.2010.11.063 104 ZhangY.TaoG