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The immunomodulatory metabolite itaconate derived from the TCA cycle was significantly boosted as a result of decreased isocitrate dehydrogenase 2 and increased immune-responsive gene 1 and mitochondrial citrate carrier in dapagliflozin-treated mice, accounting for the inhibitory effect of dapagliflozin on NLRP3 inflammasome activation (155)

Analysis of root-mean-square deviation (RMSD) of GLRX over the course of MD simulations before and after each mutation confirmed that the overall fold of GLRX was not altered by these mutations (Supplementary Fig

The pharmacy later provided it to people with Parkinsons disease, Huntington disease, chronic sinusitis, Down syndrome, and autism

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Important early changes occur before severe cell damage take place but no universal markers have yet been identified 21

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