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In comparative studies, GHK-Cu demonstrates stronger collagen-stimulating activity and broader gene modulation scope than AHK-Cu, likely due to differences in copper binding affinity and cellular uptake kinetics

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To further understand the role played by the RRM2 gene in the whole biological behavior of tumors, we performed a pan-cancer analysis by the combination of TCGA and GTEx data, which showed that RRM2 was generally highly expressed in tumors of epithelial origin, such as THCA, esophageal carcinoma, and breast carcinoma, suggesting that its pro-carcinogenic mechanism is conserved by the cancer species

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