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System Xc -, located on the cell membrane, is a heterodimer linked by disulfide bonds and contains the heavy chain subunits solute carrier family 3 member 2 and solute carrier family 7 member 11 (SLC7A11) (60)

Characterization of the stress-inducing effects of homocysteine

The results of these studies are in general agreement with the findings in patients receiving hyperbaric oxygen therapy, although frank nuclear opacities are rarely seen

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Consequently, these toxin-based models do not fully recapitulate the human disease pathology and may therefore yield results that are not directly applicable to clinical settings (Potashkin et al., 2011)

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