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These PROTACs target tau protein, phosphokinase GSK-3, HDACs, BET proteins, and transthyretin (TTR)-A interaction, exhibiting characteristics such as low dosage requirements, high efficacy, and high target selectivity

In contrast, results related to total protein, total fat, ghrelin, and cytokines remain inconsistent, while evidence suggesting the absence of a circadian rhythm for IgA and lactoferrin has increased

Challenges for clinical application Although growing evidence supports the therapeutic potential of KD in neurodegenerative disorders, its practical application in clinical settings remains challenging

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Therefore, migraine patients who meet the criteria for prophylaxis should undergo standardized prophylactic treatment, which can reduce the severity of their migraine attacks and have a higher overall efficacy

Int J Nanomedicine 19:1010710128