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"Thyroid physiology and diagnostic evaluation of patients with thyroid disorders." Williams textbook of endocrinology: 334

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This failure is largely due to testing exclusively on cancer cell lines grown in liquid medium, a condition that predicts in vivo efficacy to anticancer drugs worse than cell culture in 3D gels [4, 5] and is far from adequately reflecting the therapeutic responsiveness of cancers within their native microenvironment [2, 3]

doi: 10.1016/j.nbd.2018.10.001, 108

A.Rodrguez-SnchezI

NF-kB is a master transcription factor that controls the expression of hundreds of genes involved in inflammation, immune activation, and cell survival