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The Newcastle Ottawa Scale [53] for case control studies was modified to assess the methodological quality of observational articles for the review (Table 1)

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Elderly patients infected with SARS-CoV-2 frequently experience rapid disease progression due to high expression of PD-1 and Tim-3 on CD8 + T cells and dysregulated innate immunity, culminating in cytokine storms dominated by IL-6 and granulocytemacrophage colonystimulating factor (GM-CSF)

Shaker E, Mahmoud H, Mnaa S