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However, empirical evidence shows that this is not the case

Since the phenolic group of 4-hydroxythalidomide can act as a nucleophile in the presence of reagents such as triphenylphosphine (TPP or PPh 3 ) and diisopropylazodicarboxylate (DIAD) or similar, it is possible to introduce linkers bearing a primary or secondary alcohols, via Mitsunobu reactions 93,116

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