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Data analyses All data are presented as mean SEM and were analyzed by one-way and two-way ANOVA followed by Bonferroni corrections for multiple comparisons between means using the error mean square terms from each ANOVA analysis as described previously 36

Cellular ROS detection assay Following spheroids treatment with different Vit-C doses for 72 h, the cellular ROS was determined by performing the ROS-GLO H 2 O 2 ASSAY (PROYY-G8820, Promega, USA) according to the protocol from the manufacturer

The harvested bacterial cells were suspended in TBS buffer

Unprecedented blue intrinsic photoluminescence from hyperbranched and linear polyethylenimines: polymer architectures and pH-effects

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& Sziklai-Lszl, I.) (1998)