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J., Mercer, G

Under hypoxic or ER stress conditions, ATF4 upregulates BH3-only proteins such as HRK, PUMA , and NOXA , which influence mitochondrial integrity and autophagy

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In the brain, accumulation of misfolded A proteins forms plaques that induce local inflammatory responses, attracting immune cells such as microglia ( Figure 5 )

Other factors impacting bone health may include cellular changes, genetic damage due to complex age-related changes as well as nutritional deficiencies of calcium and vitamin D