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These effects are diminished or lost in 3-KO mice, indicating that 3-AR signaling is essential for many, but not all, of AOD9604s actions

M.DawoodA

CK activates PINK1/Parkin-mediated mitophagy in the skeletal muscle of db/db mice, upregulates the expression of mitofusion 1 (MFN1), MFN2, and optical atrophy 1 (OPA1), decreases the expression of fission mitochondrial 1 (FIS1), inhibits the activity of Drp1, and upregulates the expression of FA oxidation protein acyl-co an oxidase 1 (ACOX1), carnitine palmitoyltransferase 2 (CPT2) and COX6A1, along with mitochondrial DNA content