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Within endosomal vesicles, Fe 3+ undergoes six-transmembrane epithelial antigen of prostate 3 (STEAP3)-catalyzed reduction to Fe 2+ , subsequently exported to cytosol via divalent metal transporter 1 (DMT1) ( 2+ complexes are sequestered in the labile iron pool (LIP) through ferritin binding

[560] This measure also has the potential to reduce healthcare provider burden and burnout by both acknowledging patients' non-clinical needs that nevertheless greatly contribute to adverse clinical outcomes and linking providers with community-based organizations to enhance patient-centered treatment and discharge ( planning