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Description

An inwardly rectifying K(+) channel, Kir4.1, expressed in astrocytes surrounds synapses and blood vessels in brain

AM is supported by the NIHR Biomedical Research Centre University College London Hospital Conflict of interest: SH, OB, HMA, OOC, AM and KA none

The commonly referenced therapeutic range of 0.25-0.5 mg daily (250-500 mcg) extrapolates from the effective rat dose of approximately 10 mcg/kg body weight