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24 Patients with subtype C disease have significant immune cell infiltration and proinflammatory features, especially a significant increase in the activity of immune cells such as lymphocytes and macrophages

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For riboflavin and biotin almost all microbes belonging to the Bacteroidota, Fusobacteriota and Proteobacteria phyla were predicted to possess the required pathways, while a much smaller portion of Firmicutes and Actinobacteria were predicted to have to potential for vitamin B biosynthesis

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This observed decline has been confirmed by more recent studies showing impairments in memory, processing speed, attention, and general cognition, which were linked to reduced myelin content (Brickman et al., 2012