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1422-C IMPACT OF LONG-TERM TREATMENT WITH CONTINUOUS TENOFOVIR ALAFENAMIDE (TAF) OR AFTER SWITCH FROM TENOFOVIR DISOPROXIL FUMARATE (TDF) ON HEPATOCELLULAR CARCINOMA (HCC) INCIDENCE IN PATIENTS WITH CHRONIC HEPATITIS B (CHB) Young-Suk Lim 1 , Grace Lai-Hung C Wong 2 , Sang Hoon Ahn 3 , Wai-Kay Seto 4 , Kosh Agarwal 5 , Harry L

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Moreover, it promotes degeneration of epithelial cells of the proximal convoluted tubule and tubular cylinders, enhances focal mineralization, damages podocytes of the Bowman's capsule, increases serum levels of urea and creatinine, and brings about histological changes in kidney tubules ( Figure 4 ) [77,84]

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Empty pTRV2 vector was used as a control

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