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Proteomic analysis has shown that x-ray repair cross-complementing protein 1 (XRCC1) K247 lactylation enhances its binding affinity for importin- (also known as Karyopherin-), facilitating nuclear translocation and promoting DNA damage repair in tumor cells

Pizzorno Jr., ND, is a leading authority on science-based natural and integrative medicine

Assessment of obesity and cardiometabolic status by integrase inhibitor use in REPRIEVE: A Propensity-Weighted analysis of a multinational primary cardiovascular prevention cohort of people with human immunodeficiency virus

the POI is released from the ELP-intein complex, which is selectively removed by a second round of ammonium sulfate precipitation and centrifugation, giving rise to POI of high purity in solution

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Abstract Despite advances in immunotherapy, triple-negative breast cancer (TNBC) remains a major therapeutic challenge owing to its marked aggressiveness, low immunogenicity, and limited responsiveness to immune checkpoint blockade (ICB)