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SNCA + GPX4 OE mice

These studies demonstrate that metformin: Reduces levels of an enzyme that generates beta-amyloid proteins 32 Decreases the harmful effect of beta-amyloid on brain cell function 39-41 Reduces levels of alpha synuclein , another protein that accumulates and causes damage in Parkinsons disease 42 Prevents the loss of dopamine-producing brain cells in a model of Parkinsons disease 43,44 Improves motor coordination in a mouse model of Parkinsons 45 In 2016, a human study showed that taking 1,000 mg of metformin twice daily for 12 months improved memory recall in a group of older adults with a condition called amnestic mild cognitive impairment (a memory-stealing predecessor of Alzheimers)

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Neurotox Res 1:2739 Stone JR, Yang S (2006) Hydrogen peroxide: a signaling messenger