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[] Small-molecule agonists targeting ERR activity (e.g., SLU-PP-332 and SLU-PP-915) show promise in animal studies, but their efficacy and safety in patients remain to be evaluated in clinical trials

Magis D, Ambrosini A, Sndor P, Jacquy J, Laloux P, Schoenen J

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Another possibility is that obesity could lower serum vitamin B12 levels through decreased dietary intake or absorption, increased catabolism, and sequestration in adipose tissue, or changes in the gut microbiota profiles which could affect the metabolism of vitamin B12