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It can be done from the same blood sample taken for the primary test

The Holotranscobalamin Test (Holo-TC): A look at active B12 While the serum test measures the total amount of vitamin B12, there's a more precise method that hits the nail on the head: the holotranscobalamin test, or Holo-TC for short

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In both the US NHANES 2011 and 20132014 surveys, non-Hispanic white persons had higher serum MMA (about 25%) concentrations than non-Hispanic black persons, even after adjustment for other covariates (Mineva et al., 2019)

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