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At therapeutic doses, gut absorption becomes the limiting factor IV delivery removes that ceiling

Plant Cell Environ 34:179191

This raises the notion that perhaps within konzo-prone regions of sub-Saharan Africa there may be genetic variants of GPx3, or genes related to associated pathways that circulate which could alter gene expression and subsequently cause a reduction of protein abundances in these populations

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This transport mechanism ensures bilirubin remains within the vascular compartment, preventing tissue deposit and toxicity

10.1016/j.jep.2018.05.019 [DOI] [PubMed] [Google Scholar] Bandyopadhyay D., Mirsaeidi M