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After incubation with TCM along with NFX, cells were gradually polarized into M1 or M2 type macrophages, while ROS significantly inhibited the formation of M1 type macrophages and tended to induce the M2 type macrophages, which is consistent with previous studies indicating that ROS promote macrophage immunosuppressive features [38,39,40]

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S1406: Randomized phase II study of irinotecan and cetuximab with or without vemurafenib in BRAF-mutant metastatic colorectal cancer (mCRC)