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Oxidative stress plays a pivotal role in podocyte injury, proteinuria, segmental glomerulosclerosis, and tubulointerstitial fibrosis by activating specific pathways and interacting with the TGF-/Smad signaling pathway to drive renal fibrosis [33]

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Oncol Lett 15:87358743 Patlevi P, Vakov J, vorc P Jr, Vako L, vorc P (2016) Reactive oxygen species and antioxidant defense in human gastrointestinal diseases

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Small, sustained changes in body composition build up slowly, so give any supplement trial at least 8 to 12 weeks before judging its effect