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Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors

Parameters are described in Supplementary Table 3

For example, SLC39A8 co-transports Zn and Mn, and its loss of function concurrently reduces renal levels of both metals, highlighting its intricate role in maintaining metal homeostasis 117

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However, when the acute inflammatory response is self-limited through NETs and AGGNets, residual immune stimulation can cause inflammation to transition from a reversible acute phase to a chronic remodeling phase if the crystals are not completely removed (137)

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