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Its inclusion in advanced research protocols makes it a recognised option for those building multi-compound or stacking-based research approaches

Further, long-term use of acid-reducing drugs and the anti-diabetes drug metformin and repeated exposure to nitrous oxide have been implicated in vitamin B 12 deficiency (see Drug interactions)

It has been studied in research settings for its ability to stimulate the pituitary glands natural growth hormone release pathway

References Nair R, Maseeh Vitamin D: The sunshine vitamin

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A dietary cause is often managed with daily tablets, or an injection about twice a year